NCIt definition : A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the
binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4,
resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement
into the peripheral circulation.;
Alternative definition : NCI-GLOSS: A drug used before autologous stem cell transplantation in patients with
non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony
stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood.
The stem cells can then be collected, stored, and given back to the patient. Plerixafor
is a type of chemokine receptor antagonist.;
UNII : S915P5499N;
InChIKey : YIQPUIGJQJDJOS-UHFFFAOYSA-N;
CAS number : 110078-46-1;
Drug name : Mozobil;
Molecule name : AMD 3100; SDZ SID 791; JM-3100; AMD-3100;
Chemical formula : C28H54N8;
Codes from synonyms : CDR0000631492; CDR0000631490; CDR0000415553; 407;