" /> Plerixafor - CISMeF





Preferred Label : Plerixafor;

NCIt synonyms : 1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane;

NCIt related terms : AMD 3100; Mozobil;

NCIt definition : A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.;

Alternative definition : NCI-GLOSS: A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. Plerixafor is a type of chemokine receptor antagonist.;

UNII : S915P5499N;

InChIKey : YIQPUIGJQJDJOS-UHFFFAOYSA-N;

CAS number : 110078-46-1;

Drug name : Mozobil;

Molecule name : AMD 3100; SDZ SID 791; JM-3100; AMD-3100;

Chemical formula : C28H54N8;

Codes from synonyms : CDR0000631492; CDR0000631490; CDR0000415553; 407;

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30/05/2025


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