Collagen Alpha-1(V) Chain

Preferred Label : Collagen Alpha-1(V) Chain;

NCIt synonyms : Alpha 1 Type V Collagen; Collagen Type V Alpha 1; COL5A1; Collagen Type V Alpha 1 Chain; Type V Preprocollagen Alpha 1 Chain;

NCIt definition : Collagen alpha-1(V) chain (1838 aa, 184 kDa) is encoded by the human COL5A1 gene. This protein plays a role in the development and structural integrity of connective tissues.;

NCIt note : Collagen alpha-1(V) chain is a constituent of type V collagen fibrils. Type V fibrillar collagen has several forms, the most common form is a trimer comprised of two collage alpha-1(V) chains and one alpha-2(V) chain. A placental form is a heterotrimer containing one alpha-1(V) chain, one alpha-2(V) chain, and one alpha-3(V) chain. In rare instances type V collage is found as homotrimer comprised of three alpha-1(V) chains. (OMIM and UniProt);

Details

Origin ID

C177527;

UMLS CUI

C5444631;

Automatic exact mappings (from CISMeF team)
- Collagen, type V, alpha-1 [OMIM gene]
- collagen type V alpha 1 chain [ORDO Gene]
- collagen type V alpha 1 chain [HGNC gene]
OMIM relation
- Collagen, type V, alpha-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- COL5A1 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Integrin Angiogenesis Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Eye Development [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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