Preferred Label : Vibostolimab/Pembrolizumab MK-7684A;
NCIt synonyms : Co-formulated Product Vibostolimab plus Pembrolizumab; Vibostolimab/Pembrolizumab; Vibostolimab-Pembrolizumab; MK-7684/MK-3475;
NCIt definition : A co-formulated product containing fixed doses of the two monoclonal antibodies vibostolimab
and pembrolizumab, with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration of vibostolimab/pembrolizumab MK-7684A, vibostolimab,
an antibody against the immune checkpoint inhibitor T-cell immunoglobulin (Ig) and
immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT; T-cell immunoreceptor
with Ig and ITIM domains; T-cell immunoglobulin and ITIM domain), targets and binds
to TIGIT expressed on various immune cells, particularly on tumor-infiltrating T-lymphocytes
(TILs) and natural killer (NK) cells, thereby preventing the interaction of TIGIT
with its ligands CD112 (nectin-2; poliovirus receptor related-2; PVRL2) and CD155
(poliovirus receptor; PVR; nectin-like protein 5; NECL-5), which are expressed on
T-cells, NK cells and certain cancer cells. This enhances the interaction of CD112
and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1),
which is expressed on immune cells, such as NK cells and CD8 T-cells, and activates
CD226-mediated signaling. This activates the immune system to exert a T-cell-mediated
immune response against cancer cells. TIGIT plays a key role in the suppression of
T-cell proliferation and activation and tumor cell immune evasion. Pembrolizumab,
an antibody directed against human cell surface receptor PD-1 (programmed death-1
or programmed cell death-1) targets and binds to PD-1, an inhibitory signaling receptor
expressed on the surface of activated T cells, and blocks the binding to and activation
of PD-1 by its ligands, which results in the activation of T-cell-mediated immune
responses against tumor cells. The ligands for PD-1 include programmed cell death
ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death
ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs).
Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor
evasion from host immunity.;
Molecule name : MK 7684A; MK-7684A;
NCI Metathesaurus CUI : CL1642602;
Origin ID : C176841;
UMLS CUI : C5447465;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
