Regulatory Factor X Complex

Preferred Label : Regulatory Factor X Complex;

NCIt synonyms : Regulatory Factor X; RFX Complex; RFX;

NCIt definition : A heterotetrameric complex that plays a role in the transcriptional activation of major histocompatibility class II genes and consists of 2 molecules of DNA-binding protein RFX5 and one each of regulatory factor X-associated protein (RFXAP) and DNA-binding protein RFXANK.;

NCIt note : Regulatory factor X binds to X-box sequences in gene promoters. (UniProt);

NCI Metathesaurus CUI : CL1642445;

Details

Origin ID

C176557;

UMLS CUI

C0128400;

Automatic exact mappings (from CISMeF team)
- Regulatory Factor X1 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Regulatory Factor X1 [MeSH Descriptor]
gene_product_has_biochemical_function
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Activation [NCIt concept]
has_gene_product_element
- DNA-Binding Protein RFX5 [NCIt concept]
- DNA-Binding Protein RFXANK [NCIt concept]
- Regulatory Factor X-Associated Protein [NCIt concept]
related_to_genetic_biomarker
- RFX5 Gene [NCIt concept]
- RFXANK Gene [NCIt concept]
- RFXAP Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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