Volume-Regulated Anion Channel Subunit LRRC8A

Preferred Label : Volume-Regulated Anion Channel Subunit LRRC8A;

NCIt synonyms : LRRC8A; Swelling Protein 1; Leucine-Rich Repeat-Containing Protein 8A;

NCIt definition : Volume-regulated anion channel subunit LRRC8A (810 aa, 94 kDa) is encoded by the human LRRC8A gene. This protein is involved in the maintenance of cell volume.;

NCIt note : Barttin forms heteromers with chloride channel protein ClC-Ka (CLCNKA) in the thin ascending limb of the loop of Henle and with chloride channel protein ClC-Kb (CLCNKB) in the thick ascending limb and more distal segments of the loop of Henle. (UniProt);

Details

Origin ID

C176556;

UMLS CUI

C5444213;

OMIM relation
- Leucine-rich repeat-containing protein 8a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Ion Channel Protein Gene [NCIt concept]
- LRRC8A Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Ion Channel [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Osmotic Activity [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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