Insulin-Like Growth Factor-Binding Protein 6

Preferred Label : Insulin-Like Growth Factor-Binding Protein 6;

NCIt synonyms : IGFBP-6; Insulin-Like Growth Factor Binding Protein 6; IGFBP6; IGF Binding Protein 6; IGF-Binding Protein 6; Insulin-Like Growth Factor-Binding Protein-6; IBP-6;

NCIt definition : Insulin-like growth factor-binding protein 6 (240 aa, 25 kDa) is encoded by the human IGFBP6 gene. This protein plays a role in insulin-like growth factor binding.;

NCIt note : IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI);

Details

Origin ID

C17587;

UMLS CUI

C1442822;

Currated CISMeF NLP mapping
- Insulin-Like growth factor binding protein 6 [MeSH Descriptor]
- Insulin-Like growth factor binding protein 6 [MeSH concept]
OMIM relation
- Insulin-like growth factor-binding protein 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- IGFBP6 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Risk Marker [NCIt concept]
gene_product_is_element_in_pathway
- Food Intake and Energy Homeostasis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Inhibition of Cell Proliferation [NCIt concept]
- Intracellular Signaling Process [NCIt concept]
- Intracellular Transport [NCIt concept]
- Ligand Binding [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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