Transcription Elongation Factor SPT5

Preferred Label : Transcription Elongation Factor SPT5;

NCIt synonyms : Transcription Initiation Protein SPT5; SUPT5H; Chromatin Structure Regulator Homolog; Suppressor of TY 5 Homolog; DSIF p160; DSIF Large Subunit; Tat-CT1 Protein; DRB Sensitivity-Inducing Factor Large Subunit; hSPT5; SPT5 Protein; DRB Sensitivity-Inducing Factor 160 kDa Subunit; Tat-Cotransactivator 1 Protein;

NCIt definition : Transcription elongation factor SPT5 (1087 aa, 121 kDa) is encoded by the human SUPT5H gene. This protein plays a role in both transcriptional regulation and mRNA processing.;

NCIt note : Believed to be part of a transcriptional-repression protein complex involved in modulating chromatin structure. The SPT5 amino terminus is highly acidic, while the C-terminus contains seven Mitogen-Activated Protein (MAP) Kinase consensus sequences. (OMIM 602102 and NCI);

Details

Origin ID

C17537;

UMLS CUI

C0674839;

OMIM relation
- Spt5 homolog, dsif elongation factor subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SPT5 transcriptional elongation factor [MeSH Supplementary Concept]
- SPT5 transcriptional elongation factor [MeSH concept]
- SUPT5H protein, human [MeSH Supplementary Concept]
- SUPT5H protein, human [MeSH concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SUPT5H Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- RNA Processing [NCIt concept]
- Transcription Elongation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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