Preferred Label : Remimazolam Besylate;
NCIt synonyms : Remimazolam Benzenesulfonate;
NCIt definition : The besylate ester form of remimazolam, a short-acting benzodiazepine derivative that
is structurally related to midazolam, with sedative-hypnotic activity. Upon administration,
remimazolam targets and binds to a specific site on the gamma-aminobutyric acid (GABA)-A-chloride
ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric
modification of the receptor thereby enhancing the affinity of GABA to the receptor
leading to an increase in the frequency of chloride-channel opening events, which
leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition
of the action potential, and a decrease in neuronal excitability.;
UNII : 280XQ6482H;
InChIKey : QMTKNJZIWGTNTE-LMOVPXPDSA-N;
CAS number : 1001415-66-2;
NCI Metathesaurus CUI : CL1636311;
Origin ID : C175198;
UMLS CUI : C5390017;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
https://www.ema.europa.eu/en/medicines/human/EPAR/byfavo
2021
false
false
false
Netherlands
French
English
remimazolam
remimazolam
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
remimazolam
hypnotics and sedatives
hypnotics and sedatives
adult
conscious sedation
injections, intravenous
product surveillance, postmarketing
Remimazolam Besylate
Remimazolam Besylate
drug interactions
pregnancy
breast feeding
GABA agents
GABA agents
diagnostic techniques and procedures
drug evaluation, preclinical
benzodiazepines
benzodiazepines
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