Histone H2B - CISMeF

Preferred Label : Histone H2B;

NCIt synonyms : Histone-H2B;

NCIt related terms : H2B;

NCIt definition : Histone H2B is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI);

Alternative definition : CDISC: An antigen in the core histone family and a subunit of the nucleosome complex, with a designation of H2B. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.;

Details

Origin ID

C17460;

UMLS CUI

C0086411;

Currated CISMeF NLP mapping
- Histone H2B [FMA entity]
- Histone H2b [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histone H2B [FMA entity]
- Histone H2b [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Histone Gene [NCIt concept]
- Histone H2 Gene [NCIt concept]
- Histone H2B Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
- Nucleosome [NCIt concept]
- Nucleosome Core Particle [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Chromatin Structural Process [NCIt concept]
- Transcription Elongation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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