" /> Histone H2B - CISMeF





Preferred Label : Histone H2B;

NCIt synonyms : Histone-H2B;

NCIt related terms : H2B;

NCIt definition : Histone H2B is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI);

Alternative definition : CDISC: An antigen in the core histone family and a subunit of the nucleosome complex, with a designation of H2B. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.;

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09/07/2025


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