Hyaluronidase PH-20

Preferred Label : Hyaluronidase PH-20;

NCIt synonyms : Sperm Surface Protein PH-20; SPAM1; Sperm Adhesion Molecule-1; Sperm Adhesion Molecule 1; EC 3.2.1.35; Hyaluronoglucosaminidase PH-20;

NCIt definition : Hyaluronidase PH-20 (509 aa, 58 kDa) is encoded by the human SPAM1 gene. This protein plays a role in sperm-egg adhesion, hyaluronic acid catabolism and sperm entry.;

NCIt note : Hyaluronidase PH-20 is a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. (EntrezGene);

Details

Origin ID

C17413;

UMLS CUI

C1612177;

Currated CISMeF NLP mapping
- hyaluronidase PH-20 [MeSH concept]
- hyaluronidase PH-20 [MeSH Supplementary Concept]
OMIM relation
- Sperm adhesion molecule 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SPAM1 protein, human [MeSH concept]
- hyaluronidase PH-20 [MeSH Supplementary Concept]
- hyaluronidase PH-20 [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- SPAM1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Testicular Tissue [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Fertilization [NCIt concept]
- Hydrolysis [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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