Tumor Suppressor Gene

Preferred Label : Tumor Suppressor Gene;

NCIt synonyms : Anti-Oncogene; Tumor Suppressor; Tumor Suppressors;

NCIt related terms : antioncogene;

NCIt definition : Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI);

Alternative definition : NCI-GLOSS: A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in antioncogenes may lead to cancer.;

Codes from synonyms : CDR0000046657; CDR0000583866;

Details

Origin ID

C17362;

UMLS CUI

C0079427;

Currated CISMeF NLP mapping
- antioncogene [SNOMED Notion]
- genes, tumor suppressor [MeSH Descriptor]
- genes, tumor suppressor [MeSH concept]
- obsolete tumor suppressor [GO term]
False automatic mappings
- Antioncogene (substance) [SNOMED CT concept]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Antioncogene (substance) [SNOMED CT concept]
- antioncogene [SNOMED Notion]
- genes, tumor suppressor [MeSH concept]
- genes, tumor suppressor [MeSH Descriptor]
gene_encodes_gene_product
- Candidate Tumor Suppressor Protein [NCIt concept]
- Coiled-Coil Domain-Containing Protein 6 [NCIt concept]
- Deleted in Esophageal Cancer 1 [NCIt concept]
- Deleted in Lung and Esophageal Cancer Protein 1 [NCIt concept]
- Folliculin [NCIt concept]
- H19 Opposite Tumor Suppressor [NCIt concept]
- Leukemia-Associated Protein 1 [NCIt concept]
- Melanoma-Derived Growth Regulatory Protein [NCIt concept]
- Platelet-Derived Growth Factor Receptor-Like Protein [NCIt concept]
- Protein CBFA2T2 [NCIt concept]
- Protein TSSC4 [NCIt concept]
- Ras Association Domain-Containing Protein 5 [NCIt concept]
- Tumor Suppressor Protein [NCIt concept]
- von Willebrand Factor A Domain-Containing Protein 5A [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Tumor Suppression [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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