" /> Tobemstomig - CISMeF





Preferred Label : Tobemstomig;

NCIt synonyms : Anti-PD1/Anti-LAG3 Bispecific Antibody RO7247669; Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669;

NCIt definition : A bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; Programmed Death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tobemstomig targets and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits the PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. This may lead to cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles in suppressing T-cell activation and proliferation.;

UNII : 93NRF4S9HR;

CAS number : 2648839-43-2;

Molecule name : RO-7247669; RO 7247669;

NCI Metathesaurus CUI : CL1407490;

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07/05/2025


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