Troponin I - CISMeF

Preferred Label : Troponin I;

NCIt synonyms : TnI; Troponin-I; TNNI;

NCIt definition : Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions. The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac. (from OMIM 191044, 191043, 191042 and NCI);

Details

Origin ID

C17343;

UMLS CUI

C0077401;

Automatic exact mappings (from CISMeF team)
- Troponin T/I [ICHI extension code]
- troponin I2, fast skeletal type [HGNC gene]
Currated CISMeF NLP mapping
- Troponin I [MedDRA Preferred Term]
- Troponin-I [FMA entity]
- troponin I [MeSH concept]
- troponin i [MeSH Descriptor]
- troponin i [SNOMED Notion]
False automatic mappings
- Troponin I (substance) [SNOMED CT concept]
- troponin I (104-115) [MeSH concept]
- troponin I (104-115) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Troponin I (substance) [SNOMED CT concept]
- Troponin-I [FMA entity]
- troponin I [MeSH concept]
- troponin i [SNOMED Notion]
- troponin i [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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