DBL Oncoprotein

Preferred Label : DBL Oncoprotein;

NCIt synonyms : p66; MCF2; MCF2 Oncoprotein; DBL;

NCIt definition : Human MCF2 Oncoprotein is a product of a mutated variant (Oncogene MCF2) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. MCF2 Oncoprotein disrupts normal cell function.;

Details

Origin ID

C17316;

UMLS CUI

C0069500;

OMIM relation
- Mcf.2 cell line-derived transforming sequence [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- MCF2 Gene [NCIt concept]
- Oncogene [NCIt concept]
- Oncogene DBL [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Ovary [NCIt concept]
- Testis [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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