Haptoglobin-Related Protein

Preferred Label : Haptoglobin-Related Protein;

NCIt synonyms : HPR;

NCIt definition : Haptoglobin-related protein (348 aa, 39 kDa) is encoded by the human HPR gene. This protein plays a role in hemoglobin binding.;

NCIt note : Haptoglobin-related protein (trypanosome lytic factor) confers human resistance to Trypanosome brucei. HPR or HPR-like epitopes are expressed in human breast carcinoma. Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor.; Although homologous to serine proteases, haptoglobin-related protein is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt);

Details

Origin ID

C17299;

UMLS CUI

C0062120;

OMIM relation
- Haptoglobin-related protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
gene_encodes_gene_product
- HPR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Serum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_biomarker_of
- Breast Carcinoma [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Marker [NCIt concept]
gene_product_malfunction_associated_with_disease
- Hepatocellular Adenoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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