Efgartigimod Alfa

Preferred Label : Efgartigimod Alfa;

NCIt synonyms : Efgartigimod Alfa-fcab;

NCIt definition : A human immunoglobulin G1 (IgG1)-derived Fc fragment that targets the neonatal Fc receptor (FcRn), with potential FcRn blocking activity. Upon administration, efgartigimod alfa targets, binds to and blocks FcRn, thereby preventing FcRn from recycling IgG back into the systemic circulation. This causes a reduction in IgG blood levels, including the abnormal acetylcholine receptor (AChR) antibodies that are present in myasthenia gravis. FcRn binds to IgGs and prevents their lysosomal degradation, thereby extending IgG half-life and increases the availability of pathogenic IgG antibodies that are present in certain severe autoimmune diseases.;

UNII : 961YV2O515;

CAS number : 1821402-21-4;

Drug name : Vyvgart;

Molecule name : ARGX 113; ARGX-113;

NCI Metathesaurus CUI : CL1405994;

Détails

Origin ID

C171817;

UMLS CUI

C5139924;

Currated CISMeF NLP mapping
- Efgartigimod alfa [SMS substance]
- efgartigimod alfa [MeSH Supplementary Concept]
- efgartigimod alfa [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- efgartigimod alfa [MeSH Supplementary Concept]
- efgartigimod alfa [ATC Code]
Validated automatic mappings to BTNT
- efgartigimod alfa [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

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