NCIt definition : A humanized immunoglobulin G1 (IgG1) noncytolytic monoclonal antibody directed against
the B-cell-specific cell surface antigen CD-19, Fc-engineered for increased affinity
to Fc gamma receptor IIB (FcgRIIB; CD32B), with potential immunomodulatory activity.
Upon administration, obexelimab simultaneously targets and binds to both CD19 and
FcgRIIB expressed on the surface of B-cells, and inhibits B-cell receptor (BCR) signaling
and the activity of B-cells without depleting the B-cells. This may alleviate manifestations
of autoimmune diseases including systemic lupus erythematosus (SLE). CD19 and FcgRIIB,
both expressed on the surface of B-cells, play important roles in BCR signaling, and
B-cell activity and survival.;
UNII : RM16A4BA8R;
CAS number : 1690307-05-1;
Molecule name : ZB-012; ZB 012; XMAB 5871; XMAB-5871;
Semantic type(s)