NCIt related terms : Zometa; [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid;
NCIt definition : A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption
activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite
crystals in the bone matrix, slowing their dissolution and inhibiting the formation
and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate
synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme
prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation
and geranylgeranylation during the post-translational modification of small GTPase
signalling proteins, which are important in the process of osteoclast turnover. Decreased
bone turnover and stabilization of the bone matrix contribute to the analgesic effect
of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces
serum calcium concentrations associated with hypercalcemia.;
Alternative definition : NCI-GLOSS: A drug used to treat patients with hypercalcemia (high blood levels of
calcium) caused by cancer. It is also used together with other drugs to treat multiple
myeloma and to prevent bone fractures and reduce bone pain in people who have cancer
that has spread to the bone. It is a type of bisphosphonate.;
UNII : 6XC1PAD3KF;
InChIKey : FUXFIVRTGHOMSO-UHFFFAOYSA-N;
CAS number : 165800-06-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 165800-06-6
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G-SRS /a ;
Drug name : Zometa; Reclast; Aclasta;
Molecule name : CGP42446A; ZOL 446; CGP 42446;
Chemical formula : C5H10N2O7P2.H2O;
NSC code : 721517;
Codes from synonyms : CDR0000487473; 50451; CDR0000045500; CDR0000487470; 550;