NCIt definition : The disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate
analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite
crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase,
thereby preventing protein prenylation within the mevalonate pathway. This leads to
the loss of downstream metabolites essential for osteoclast function, leading to the
induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated
bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.;
Currated CISMeF NLP mapping