Epoxide Hydrolase 1

Preferred Label : Epoxide Hydrolase 1;

NCIt synonyms : Epoxide Hydroxylase 1, Microsomal; Epoxide Hydratase; mEH; Epoxide Hydroxylase 1, Microsomal (Xenobiotic); EPHX1; EC 3.3.2.9; Microsomal Epoxide Hydrolase;

NCIt definition : Epoxide hydrolase 1 (455 aa, 53 kDa) is encoded by the human EPHX1 gene. This protein is involved in the hydrolysis of cyclic organic compounds.;

NCIt note : Expression of microsomal epoxide hydrolase (mEH), a carcinogen-activating enzyme, in primary breast tumors may predict poor response to tamoxifen treatment. (from J Clin Oncol 2001;19:3-9 via Medscape);

Details

Origin ID

C16860;

UMLS CUI

C2001855;

Currated CISMeF NLP mapping
- microsomal epoxide hydrolase [MeSH concept]
OMIM relation
- Epoxide hydrolase 1, microsomal [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- EPHX1 protein, human [MeSH Supplementary Concept]
- EPHX1 protein, human [MeSH concept]
- microsomal epoxide hydrolase [MeSH concept]
gene_encodes_gene_product
- EPHX1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Marker [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Malignant Breast Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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