Immunoglobulin Light Chain, Lambda

Preferred Label : Immunoglobulin Light Chain, Lambda;

NCIt synonyms : IGL; Ig Light Chain Lambda; Immunoglobulin Lambda; Ig Lambda Chain; Lambda Light Chain; Immunoglobulin Light Chain Lambda; Immunoglobulin Lambda Light-Chain; Immunoglobulin Lambda Light Chain; Immunoglobulin Lambda Chain;

NCIt definition : Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains but Ig lambda light chains contain a variable and a constant region. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. During differentiation of an activated (lambda-type) antibody-producing B-cell, diversity in the lambda light chain V region arises from variable recombination of lambda V genes with lambda J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM 147220 and NCI);

Details

Origin ID

C16719;

UMLS CUI

C0021037;

Automatic exact mappings (from CISMeF team)
- IgM.lambda [LOINC component]
- Immunoglobulin lambda constant region 1 [OMIM gene]
- Immunoglobulin, L chain, lambda (substance) [SNOMED CT concept]
- immunoglobulin lambda-Chains [MeSH concept]
- immunoglobulin lambda-chains [MeSH Descriptor]
- immunoglobulin, l chain, lambda [SNOMED Notion]
- indole-3-glycerol-phosphate lyase activity [GO term]
- lambda-x immunoglobulin [MeSH concept]
Currated CISMeF NLP mapping
- Lambda light chains [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Immunoglobulin, L chain, lambda (substance) [SNOMED CT concept]
- Lambda light chains [LOINC part]
- Lambda light chains [LOINC component]
- immunoglobulin lambda-Chains [MeSH concept]
- immunoglobulin lambda-chains [MeSH Descriptor]
- immunoglobulin, l chain, lambda [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoglobulin Lambda Locus [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Immunoprotein [NCIt concept]
- Ligand Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin Hypervariable Region [NCIt concept]
- Immunoglobulin Joining Region [NCIt concept]
- Immunoglobulin Variable Region [NCIt concept]
gene_product_is_physical_part_of
- Immunoglobulin [NCIt concept]
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Humoral Immunity [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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