" /> Immunoglobulin Lambda Locus - CISMeF





Preferred Label : Immunoglobulin Lambda Locus;

NCIt synonyms : Immunoglobulin Lambda Gene; Lambda Light Chain Gene;

NCIt related terms : IGL;

NCIt definition : This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink);

GenBank Accession Number : NG_000002;

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31/07/2025


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