Immunoglobulin Light Chain, Kappa

Preferred Label : Immunoglobulin Light Chain, Kappa;

NCIt synonyms : IGK; Immunoglobulin Kappa Chain; Immunoglobulin Kappa; Immunoglobulin Kappa Light Chain; Immunoglobulin Kappa Light-Chain; Ig Light Chain Kappa; Immunoglobulin Light Chain Kappa; Kappa Light Chain; Ig Kappa Chain;

NCIt definition : Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI);

Details

Origin ID

C16718;

UMLS CUI

C0021036;

Automatic exact mappings (from CISMeF team)
- IgK [MeSH Supplementary Concept]
- IgK [MeSH concept]
- IgM.kappa [LOINC component]
- Immunoglobulin, L chain, kappa (substance) [SNOMED CT concept]
- immunoglobulin kappa-Chains [MeSH concept]
- immunoglobulin kappa-chains [MeSH Descriptor]
- immunoglobulin light chains, surrogate [MeSH Descriptor]
- immunoglobulin, l chain, kappa [SNOMED Notion]
- surrogate immunoglobulin kappa light chain [MeSH concept]
Currated CISMeF NLP mapping
- Kappa light chains [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Immunoglobulin, L chain, kappa (substance) [SNOMED CT concept]
- Kappa light chains [LOINC component]
- immunoglobulin kappa-Chains [MeSH concept]
- immunoglobulin kappa-chains [MeSH Descriptor]
- immunoglobulin, l chain, kappa [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoglobulin Kappa Locus [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Immunoprotein [NCIt concept]
- Ligand Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin Hypervariable Region [NCIt concept]
- Immunoglobulin Joining Region [NCIt concept]
- Immunoglobulin Variable Region [NCIt concept]
gene_product_is_physical_part_of
- Immunoglobulin [NCIt concept]
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Humoral Immunity [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
has_gene_product_element
- Immunoglobulin Kappa Constant [NCIt concept]
- Immunoglobulin Kappa Variable 1-5 [NCIt concept]
- Immunoglobulin Kappa Variable 1D-13 [NCIt concept]
- Immunoglobulin Kappa Variable 4-1 [NCIt concept]
is_target
- Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes [NCIt concept]

Keyword's position in hierarchy(ies) :

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