Immunoglobulin Kappa Locus

Preferred Label : Immunoglobulin Kappa Locus;

NCIt synonyms : Kappa Light Chain Gene; Immunoglobulin Kappa Gene;

NCIt related terms : IGK;

NCIt definition : This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink);

GenBank Accession Number : NG_000833;

Details

Origin ID

C26425;

UMLS CUI

C1366332;

Automatic exact mappings (from CISMeF team)
- IgK [MeSH concept]
- IgK [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Immunoglobulin kappa light chain gene (substance) [SNOMED CT concept]
- immunoglobulin kappa light chain gene [SNOMED Notion]
- immunoglobulin kappa locus [HGNC gene]
HGNC gene
- immunoglobulin kappa locus [HGNC gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Immunoglobulin kappa light chain gene (substance) [SNOMED CT concept]
- immunoglobulin kappa light chain gene [SNOMED Notion]
- immunoglobulin kappa locus [HGNC gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Reference Gene Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoglobulin Light Chain, Kappa [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 2p12 [NCIt concept]
gene_involved_in_molecular_abnormality
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- IGK Gene Rearrangement [NCIt concept]
gene_plays_role_in_process
- Humoral Immunity [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
genetic_biomarker_related_to
- IGK Negative [NCIt concept]
- IGK Positive [NCIt concept]
- Kappa Light Chain-Restriction [NCIt concept]

Keyword's position in hierarchy(ies) :

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