Preferred Label : Histone;
NCIt related terms : histone_family; histone family;
NCIt definition : Major protein component of chromatin. Highly conserved basic proteins, originally
classified into classes based on the relative amounts of arginine and lysine in each
protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin,
they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed
with DNA in nucleosomes. The histones in the octamer complex are also known as the
core histones. The H1 class of histones, termed the linker histones, is loosely associated
with the nucleosome.;
Alternative definition : NCI-GLOSS: A type of protein found in chromosomes. Histones bind to DNA, help give
chromosomes their shape, and help control the activity of genes.; CDISC: Any antigen(s) of the histone nuclear protein family. They can be considered
as autoantigens and are commonly associated with the autoimmune diseases systemic
lupus erythematosus and rheumatoid arthritis.;
ChEBI ID : CHEBI:15358;
Codes from synonyms : CDR0000318814;
Origin ID : C16687;
UMLS CUI : C0019652;
Automatic exact mappings (from CISMeF team)
- Biochemical function of gene products
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_organism_source
- gene_product_plays_role_in_biological_process
