Preferred Label : Garadacimab;
NCIt definition : A humanized monoclonal antibody against the activated coagulation factor XIIa (FXIIa),
with potential anti-inflammatory and anticoagulant activities. Upon administration,
garadacimab targets and binds to FXIIa, blocking the activation of both the kallikrein-kinin
system and the intrinsic pathway of coagulation. Blocking the activation of the kallikrein-kinin
system may reduce inflammation as well as the production of bradykinin (BK). This
may prevent BK-driven edema in hereditary angioedema (HAE). Blocking the activation
of the intrinsic pathway of coagulation may lead to anti-coagulation. This may also
prevent or improve pulmonary edema not associated with HAE and improve the associated
decrease in blood oxygen levels.;
UNII : 32W6AJL0DY;
CAS number : 2162134-62-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2162134-62-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : CSL 312; CSL-312;
NCI Metathesaurus CUI : CL971884;
Origin ID : C166633;
UMLS CUI : C5238067;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
