factor xiia - CISMeF

Preferred Label : factor xiia;

MeSH definition : Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.;

MeSH synonym : activator, prekallikrein; coagulation factor xiia; activated factor xii; factor xii, activated; factor xiia, coagulation; prekallikrein activator; blood coagulation factor xii, activated; Factor Twelve A; Factor 12A;

CISMeF synonym : xiia, coagulation factor;

MeSH hyponym : Hageman-Factor fragments; Fragments, Hageman-Factor; Hageman Factor Fragments;

Registry Number MeSH : EC 3.4.21.38;

MeSH annotation : /defic FACTOR XII DEFICIENCY;

Wikipedia link : https://en.wikipedia.org/wiki/Factor xiia;

Is substance : O;

UNII : EC 3.4.21.38;

Details

Origin ID

D015956;

UMLS CUI

C0015527;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- CMTI protein, cucurbita maxima [MeSH Supplementary Concept]
Record concept(s)
- Hageman-Factor fragments [MeSH concept]
- factor XIIa [MeSH concept]
See also
- coagulants [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Coagulation factor XIIa (substance) [SNOMED CT concept]
- coagulation factor xiia [SNOMED Notion]
Validated automatic mappings to BTNT
- Factor XII Activity Measurement [NCIt concept]

Keyword's position in hierarchy(ies) :

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