Preferred Label : Fostemsavir Tromethamine;
NCIt related terms : Rukobia;
NCIt definition : The tromethamine salt form of fostemsavir, an orally bioavailable phosphonooxymethyl
prodrug of the human immunodeficiency virus type 1 (HIV-1) attachment inhibitor temsavir,
with activity against HIV. Upon oral administration, fostemsavir is hydrolyzed to
the active moiety temsavir. Temsavir targets and binds to the gp120 subunit within
the HIV-1 envelope glycoprotein gp160. This selectively inhibits the interaction between
HIV-1 virus and host cellular CD4 receptors, thereby preventing HIV-1 virus attachment.
This also inhibits gp120-dependent post-attachment steps that are needed for HIV-1
viral entry into host cells.;
UNII : 2X513P36U0;
InChIKey : RRGJSMBMTOKHTE-UHFFFAOYSA-N;
CAS number : 864953-39-9;
Drug name : Rukobia;
NCI Metathesaurus CUI : CL971853;
Origin ID : C166604;
UMLS CUI : C5238054;
Semantic type(s)
- concept_is_in_subset
https://www.ema.europa.eu/en/medicines/human/EPAR/rukobia
2021
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
Fostemsavir Tromethamine
Fostemsavir Tromethamine
fostemsavir
organophosphates
organophosphates
piperazines
piperazines
anti-hiv agents
anti-hiv agents
hiv infections
hiv fusion inhibitors
hiv fusion inhibitors
HIV-1
adult
acquired immunodeficiency syndrome
drug therapy, combination
drug resistance, multiple, viral
administration, oral
Delayed-Action preparations
product surveillance, postmarketing
aged
drug interactions
pregnancy
breast feeding
prodrugs
Temsavir
drug evaluation, preclinical
fostemsavir
fostemsavir
multiresistant HIV-1 infection
---
