Creatine Kinase B-Type

Preferred Label : Creatine Kinase B-Type;

NCIt synonyms : CKB; Creatine Kinase-B; Brain Creatine Kinase; EC 2.7.3.2; Creatine Kinase-B Chain; B-CK; Creatine Kinase;

NCIt definition : Creatine kinase B-type (381 aa, 43 kDa) is encoded by the human CKB gene. This protein plays a role in both energy homeostasis and creatine metabolism.;

NCIt note : Creatine kinase B-type forms dimers of identical or non-identical isoenzymes. With the MB heterodimer existing in myocardium and the BB homodimer existing in many tissues, especially brain. (UniProt);

Details

Origin ID

C16473;

UMLS CUI

C3714613;

Currated CISMeF NLP mapping
- Creatine kinase [MedDRA LLT]
- Creatine phosphokinase [MedDRA LLT]
- creatine kinase [SNOMED Notion]
False automatic mappings
- Creatine kinase (substance) [SNOMED CT concept]
- creatine kinase [MeSH Descriptor]
- creatine kinase [MeSH concept]
OMIM relation
- Creatine kinase, brain type [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to NTBT
- Creatine kinase [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CKB Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arginine and Proline Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Energy Metabolism Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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