Chloramphenicol O-acetyltransferase

Preferred Label : Chloramphenicol O-acetyltransferase;

NCIt synonyms : EC 2.3.1.28; cat; Chloramphenicol Acetyl Transferase; cat I; Chloramphenicol Transacetylase; cat III; cat II; Chloramphenicol-O-Acetyltransferase;

NCIt definition : Bacterial chloramphenicol-O-acetyltransferase protein (219 aa, 26 kD) is encoded by the bacterial chloramphenicol-O-acetyltransferase (cat) gene. This enzyme detoxifies the antibiotic chloramphenicol via acetylation to yield chloramphenicol 3-acetate. The presence of this enzyme confers chloramphenicol resistance to bacteria, which is used as a marker for selection in molecular techniques that utilize genetic transfection.;

Details

Origin ID

C16429;

UMLS CUI

C0008169;

Automatic exact mappings (from CISMeF team)
- 5'-chloroacetamido-5'-deoxythymidine [MeSH Supplementary Concept]
- ATH1 protein, S cerevisiae [MeSH Supplementary Concept]
- Cat [ICD-11 Extension code]
- Cat [LOINC component]
- Catalase [OMIM gene]
- Cataract [ICD-11 Category]
- Cats [IAB term]
- Family Felidae (organism) [SNOMED CT concept]
- Felis silvestris (organism) [SNOMED CT concept]
- Genus Felis (organism) [SNOMED CT concept]
- Otocolobus manul (organism) [Inactive SNOMED CT concept]
- Subfamily Felinae (organism) [SNOMED CT concept]
- catalase activity [GO term]
- chloramphenicol O-acetyltransferase activity [GO term]
- trehalase [MeSH Descriptor]
Currated CISMeF NLP mapping
- cats [MeSH Descriptor]
- cats [MeSH concept]
- chloramphenicol o-acetyltransferase [MeSH Descriptor]
False automatic mappings
- CAT [MedDRA LLT]
- CAT(12) [MeSH concept]
- chloramphenicol O-Acetyltransferase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Chloramphenicol acetyltransferase (substance) [SNOMED CT concept]
- chloramphenicol O-Acetyltransferase [MeSH concept]
- chloramphenicol acetyltransferase [SNOMED Notion]
- chloramphenicol o-acetyltransferase [MeSH Descriptor]
gene_product_has_biochemical_function
- Acyltransferase [NCIt concept]
gene_product_has_organism_source
- Bacteria [NCIt concept]
gene_product_plays_role_in_biological_process
- Acetylation [NCIt concept]
- Detoxification [NCIt concept]

Keyword's position in hierarchy(ies) :

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