Preferred Label : Liposomal Alpha Galactosylceramide;
NCIt synonyms : Liposomal alpha-GalCer; Liposomal RGI-7000; Liposomal KRN-7000;
NCIt definition : A liposomal formulation of alpha galactosylceramide, a synthetic glycolipid isolated
from the Okinawan marine sponge (Agelas mauritianus) with potential immunosuppressing
activity. Upon administration, alpha galactosylceramide serves as a ligand for CD1d
which is expressed on various antigen-presenting cells (APCs) including dendritic
cells (DCs), macrophages, and B-cells. This induces the activation of the immunoregulatory
invariant natural killer T-cells (iNKTs), which induces the expansion of tolerogenic
regulatory DCs and, in turn, regulatory T-cells (Tregs). Tregs may specifically suppress
T-cell responses against host alloantigens, thereby reducing graft rejection while
maintaining normal immune cell function. CD1d is a non-polymorphic, major histocompatibility
complex (MHC) class I-like antigen-presenting molecule with an antigen-binding groove
adapted for the presentation of lipid antigens.;
Molecule name : RGI 2001; RGI-2001;
NCI Metathesaurus CUI : CL976987;
Origin ID : C163753;
UMLS CUI : C5235655;
Semantic type(s)
- concept_is_in_subset
- has_target
