Preferred Label : Becatecarin;
NCIt synonyms : 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-; Rebeccamycin Analogue, Tartrate Salt; DEAE-Rebeccamycin; Rebeccamycin Analogue;
NCIt related terms : NSC 655649; rebeccamycin analog; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;
NCIt definition : A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic
antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase
I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion
reaction and initiating DNA cleavage and apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the families of drugs called antitumor antibiotics and topoisomerase inhibitors.;
UNII : A60X6MBU6G;
InChIKey : JSKFWUPVIZYJMR-UDOAKELVSA-N;
CAS number : 119673-08-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 119673-08-4
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G-SRS /a ;
Molecule name : BMS-181176; BMY-27557-14; XL119;
Chemical formula : C33H34Cl2N4O7;
NSC code : 655649;
Codes from synonyms : 50520; CDR0000405883; CDR0000393543; NSC0655649;
Origin ID : C1620;
UMLS CUI : C0936065;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
