LMB-7 Immunotoxin

Preferred Label : LMB-7 Immunotoxin;

NCIt synonyms : B3(Fv)-PE38 Immunotoxin; LMB-7 (Single-Chain Immunotoxin); B3(Fv)-PE38; HB21(Fv)PE40;

NCIt related terms : Immunotoxin LMB-7;

NCIt definition : A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04);

Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and kills them.;

NSC code : 659639; 658931;

Codes from synonyms : NSC0659639; CDR0000045541;

Details

Origin ID

C1619;

UMLS CUI

C0296314;

Currated CISMeF NLP mapping
- immunotoxin LMB-7 [MeSH concept]
- immunotoxin LMB-7 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- immunotoxin LMB-7 [MeSH Supplementary Concept]
- immunotoxin LMB-7 [MeSH concept]
chemical_or_drug_affects_gene_product
- Elongation Factor 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Lewis Y Antigen Binding [NCIt concept]
- Mitochondrial Damage [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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