Preferred Label : TGFbeta Receptor Ectodomain-IgG Fc Fusion Protein BMS-986416;
NCIt synonyms : TGFb Inhibitor AVID200; TGFbeta-neutralizing Agent AVID200; TGFbeta Ligand Trap AVID200; TGF-beta 1/3 Inhibitor AVID200;
NCIt related terms : AVID-200;
NCIt definition : A fusion protein composed of the ectodomain of the transforming growth factor (TGF)
beta (TGF-beta; TGFb) receptor fused to the human immunoglobulin G (IgG) Fc domain,
with potential antineoplastic, immunomodulating and anti-fibrotic activities. Upon
administration of the TGFb receptor ectodomain-IgG Fc fusion protein BMS-986416, the
fusion protein specifically and selectively targets, binds to and neutralizes the
TGF ligands TGF-beta isoform 1 (TGFb1) and 3 (TGFb3). This prevents TGF ligands from
binding to TGF receptors and prevents TGFb-mediated signaling. This abrogates TGFb1/3-mediated
immunosuppression, enhances anti-tumor immunity in the tumor microenvironment (TME)
and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor
cells leading to tumor cell death. This may lead to a reduction in TGFb-dependent
proliferation of cancer cells. By preventing TGFb1/3-mediated signaling, BMS-986416
also prevents bone marrow fibrosis and promotes the proliferation of normal hematopoietic
progenitors. TGFb, overproduced in myelodysplastic syndrome (MDS) and in many other
types of cancer, plays a key role in immunosuppression in the TME, enhances tumor
cell proliferation, and promotes cancer progression. The TGFb1 and TGFb3 isoforms
are negative regulators of hematopoiesis that play key roles in the pathogenesis and
progression of fibrotic diseases. By selectively targeting only specific isoforms
of TGFb with minimal activity against TGFb2, BMS-986416 minimizes the potential for
cardiotoxicity and promotion of metastasis. The TGFb2 isoform promotes hematopoiesis
and plays a key role in normal cardiac function while the inhibition of the TGFb2
isoform promotes metastasis.;
UNII : 6EX05GL2VK;
CAS number : 2269485-28-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2269485-28-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : AVID-200; AVID 200; BMS-986416; BMS 986416;
NCI Metathesaurus CUI : CL951620;
Origin ID : C159817;
UMLS CUI : C5554562;
Semantic type(s)
- concept_is_in_subset
- has_target
