Ectodysplasin-A2

Preferred Label : Ectodysplasin-A2;

NCIt synonyms : ED1-A2; EDA2; Ectodysplasin A Isoform 3; Ectodysplasin A2; EDA-A2; Ectodysplasin A2 Isoform; Ectodysplasin-A Isoform 3;

NCIt definition : Ectodysplasin-A2 (389 aa, 41 kDa) is encoded by the human EDA gene. This protein is involved in the positive regulation of signaling mediated by tumor necrosis factor receptor superfamily member 27.;

NCIt note : UniProt considers isoform 1A to be the canonical form of ectodysplasin-A. Ectodysplasin-A2 is produced by alternative splicing of the EDA transcript and is a ligand for TNFRSF27/EDA2R.; Ectodysplasin-A2 is processed by furin to yield a secreted form.;

NCI Metathesaurus CUI : CL951337;

Details

Origin ID

C159360;

UMLS CUI

C5202872;

Automatic exact mappings (from CISMeF team)
- Ectodysplasin a [OMIM gene]
- ectodysplasin A [ORDO Gene]
- ectodysplasins [MeSH Descriptor]
OMIM relation
- Ectodysplasin a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- EDA Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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