Clonal Hematopoiesis of Indeterminate Potential

Preferred Label : Clonal Hematopoiesis of Indeterminate Potential;

NCIt synonyms : CHIP;

NCIt definition : A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.;

NCI Metathesaurus CUI : CL937953;

Details

Origin ID

C158547;

UMLS CUI

C4761612;

Automatic exact mappings (from CISMeF team)
- Children's Health Insurance Program [MeSH Descriptor]
- French fries (substance) [SNOMED CT concept]
- Hyperthermic Intraperitoneal Chemotherapy [MeSH Descriptor]
- Microprocessors [UNESCO concept]
- STIP1 homology and U-box containing protein 1 [ORDO Gene]
- Stip1 homologous and u box-containing protein 1 [OMIM gene]
- iproplatin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- CHIP Clonal Hematopoiesis of Indeterminate Potential [MeSH concept]
Disease may have findings
- Age-Related Clonal Hematopoiesis [NCIt concept]
- Cytopenia [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Clonal haematopoiesis of indeterminate potential [MedDRA LLT]
- Clonal hematopoiesis of indeterminate potential [MedDRA LLT]
Validated automatic mappings to NTBT
- Clonal Hematopoiesis [MeSH Descriptor]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_finding
- Monoclonal Cellular Population Present [NCIt concept]
disease_has_molecular_abnormality
- Somatic Variation [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_molecular_abnormality
- ASXL1 Gene Mutation [NCIt concept]
- DNMT3A Gene Mutation [NCIt concept]
- TET2 Gene Mutation [NCIt concept]
related_to_genetic_biomarker
- ASXL1 Gene [NCIt concept]
- DNMT3A Gene [NCIt concept]
- TET2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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