Glycylpeptide N-Tetradecanoyltransferase 1

Preferred Label : Glycylpeptide N-Tetradecanoyltransferase 1;

NCIt synonyms : EC 2.3.1.97; NMT-L; Myristoyl-CoA:Protein N-Myristoyltransferase; N-Myristoyltransferase 1; NMT1; NMT 1; Type I N-Myristoyltransferase; Peptide N-Myristoyltransferase 1; Myristoyl-CoA:Protein N-Myristoyltransferase 1;

NCIt definition : Glycylpeptide N-tetradecanoyltransferase 1 (496 aa, 57 kDa) is encoded by the human NMT1 gene. This protein is involved in the irreversible transfer of myristoyl groups from tetradecanoyl-CoA to N-terminal glycines of protein substrates.;

NCIt note : UniProt reports two forms of glycylpeptide N-tetradecanoyltransferase 1 the long form (NMT-L) is the canonical form, while the short form (NMT-S; 416 aa, 48 kDa) may be the result of the use of an alternative AUG start site at codon 81.;

NCI Metathesaurus CUI : CL937855;

Details

Origin ID

C158397;

UMLS CUI

C4761409;

Automatic exact mappings (from CISMeF team)
- N-myristoyltransferase 1 [OMIM gene]
- N-myristoyltransferase 1 [HGNC gene]
OMIM relation
- N-myristoyltransferase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- NMT1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- N-Myristoylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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