Refractory Transformed Chronic Lymphocytic Leukemia

Preferred Label : Refractory Transformed Chronic Lymphocytic Leukemia;

NCIt synonyms : Refractory Richter Syndrome;

NCIt definition : Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL937655;

Details

Origin ID

C158152;

UMLS CUI

C4764085;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Fatigue [NCIt concept]
- Lymphadenopathy [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Leukemic Small Lymphocyte with Clumped Chromatin [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small Lymphocyte with Clumped Chromatin [NCIt concept]
- Transformed Neoplastic Lymphocyte [NCIt concept]
disease_has_associated_disease
- Diffuse Large B-Cell Lymphoma [NCIt concept]
- Richter Syndrome [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Refractory Disease [NCIt concept]
- Transformed Phase of Disease [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 11 [NCIt concept]
- Human Chromosome 12 [NCIt concept]
- Human Chromosome 13 [NCIt concept]
- Human Chromosome 17 [NCIt concept]
- Human Chromosome 6 [NCIt concept]
disease_mapped_to_gene
- BCL3 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12q13 [NCIt concept]
- Trisomy 12 [NCIt concept]
- del(11q22q23) [NCIt concept]
- del(13q14) [NCIt concept]
- del(17p13) [NCIt concept]
- del(6q21) [NCIt concept]
- t(14;19)(q32;q13.1) [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal BCL3 Gene Rearrangement [NCIt concept]

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