Minor Histocompatibility Antigen HA-1

Preferred Label : Minor Histocompatibility Antigen HA-1;

NCIt synonyms : HA-1(H); mHag HA-1; HA-1;

NCIt definition : A peptide antigen comprised of 9 amino acids (VLHDDLLEA) that is derived by antigen processing from a variant of Rho GTPase-activating protein 45 where the arginine at amino acid residue 139 is substituted with histidine. This peptide can be presented by MHC class I HLA-A*0201 expressing cells. The complex of this peptide with HLA-A elicits donor-cytotoxic T-lymphocyte (CTL) reactivity following treatment by HLA-identical allogenic bone marrow transplant.;

NCI Metathesaurus CUI : CL937246;

Details

Origin ID

C157551;

UMLS CUI

C0671334;

Automatic exact mappings (from CISMeF team)
- HA-1 antigen [MeSH Supplementary Concept]
- Minor histocompatibility antigen ha-1 [OMIM gene]
- mHag HA-1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- mHag HA-1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
is_target
- Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100 [NCIt concept]
- CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR [NCIt concept]
related_to_genetic_biomarker
- ARHGAP45 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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