Preferred Label : CD8 and CD4 Donor Memory T-cells-expressing HA1-Specific TCR;
NCIt synonyms : HA-1 TCR CD8 and CD4 Tm Cells; CD8 and CD4 Donor Memory T-cells-expressing pRRLSIN iC9-HA1 TCR2-RQR-CD8; HA-1 TCR T Cells;
NCIt definition : A preparation of CD4 and CD8 central memory (CM) T-lymphocytes isolated from the
peripheral blood of a transplant donor and transduced with a lentiviral vector (LV)
(pRRLSIN) expressing a minor H antigen (HA-1(H); HA1(H)) T-cell receptor (TCR) containing
the suicide gene inducible caspase 9 (iCasp9 or iC9)-HA1 TCR2-RQR-CD8 transgene (pRRLSIN
iC9-HA1 TCR2-RQR-CD8; HA-1 TCR LV), with potential immunostimulating and antineoplastic
activities. Upon intravenous administration and after allogeneic hematopoietic stem
cell transplantation (HSCT), the CD8 and CD4 donor memory T cells-expressing HA1-specific
TCR are directed to and induce selective toxicity in HA1-expressing tumor cells. iCasp9
consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V)
linked to human caspase 9. If administration of the T-cells lead to unacceptable side
effects, a dimerizing agent rimiducid (AP1903), which binds to the FKBP12-F36V drug-binding
domain and activates caspase 9, can be administered; caspase-9 activation results
in the apoptosis of the administered TCR-modified T-cells. HA1(H) is a tumor-associated
antigen (TAA) that is selectively and highly expressed on leukemic stem cells and
blasts, but not in normal non-hematopoietic cells. RQR includes a CD20 epitope, and
a CD34 epitope that facilitates both purification and cell tracking of the transduced
T-cells with an anti-CD34 monoclonal antibody.;
NCI Metathesaurus CUI : CL524582;
Origin ID : C136782;
UMLS CUI : C4526977;
Semantic type(s)
- concept_is_in_subset
- has_target
