Preferred Label : Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100;
NCIt synonyms : T-cell Receptor Engineered Donor T-Cells TSC-100; HA-1-targeting TCR-T-cells TSC-100; Allogeneic T-cell Receptor-engineered T-cells TSC-100;
NCIt definition : A preparation of donor-derived T-lymphocytes that have been genetically engineered
to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility
antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities.
Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01
positive patients, allogeneic anti-HA-1 TCR-engineered T-cells TSC-100 specifically
recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte
(CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific
antigen found on leukemia cells.;
Molecule name : TSC 100; TSC-100;
NCI Metathesaurus CUI : CL1799393;
Origin ID : C190701;
UMLS CUI : C5783869;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
