" /> Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100 - CISMeF





Preferred Label : Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100;

NCIt synonyms : T-cell Receptor Engineered Donor T-Cells TSC-100; HA-1-targeting TCR-T-cells TSC-100; Allogeneic T-cell Receptor-engineered T-cells TSC-100;

NCIt definition : A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-1 TCR-engineered T-cells TSC-100 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific antigen found on leukemia cells.;

Molecule name : TSC 100; TSC-100;

NCI Metathesaurus CUI : CL1799393;

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10/05/2024


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