Ubl Carboxyl-Terminal Hydrolase 18

Preferred Label : Ubl Carboxyl-Terminal Hydrolase 18;

NCIt synonyms : ISG15-Specific-Processing Protease; Ubiquitin Specific Protease 18; Ubl Thiolesterase 18; USP18; Ubiquitin-Specific Peptidase 18; hUBP43; Ubiquitin Thioesterase 18; 43 kDa ISG15-Specific Protease; EC 3.4.19.-; Ubiquitin-Specific Protease 18; Ubiquitin Specific Peptidase 18;

NCIt definition : Ubl carboxyl-terminal hydrolase 18 (372 aa, 43 kDa) is encoded by the human USP18 gene. This protein plays a role in the modulation of type I interferon-dependent signaling through the cleavage of ubiquitin-like protein ISG15 conjugated-proteins.;

Details

Origin ID

C156942;

UMLS CUI

C1436576;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-specific protease 18 [OMIM gene]
- ubiquitin specific peptidase 18 [ORDO Gene]
- ubiquitin specific peptidase 18 [HGNC gene]
OMIM relation
- Ubiquitin-specific protease 18 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- USP18 protein, human [MeSH concept]
- USP18 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP18 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Inflammatory Response [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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