Iptacopan - CISMeF

Preferred Label : Iptacopan;

NCIt synonyms : Factor B Inhibitor LNP023;

NCIt definition : An orally available, small-molecule inhibitor of complement factor B (FB) with potential immunomodulatory activity. Upon administration, iptacopan binds to FB and prevents the formation of the alternative pathway (AP) C3-convertase (C3bBb). This limits the cleavage of C3 to the active fragment C3b and may prevent C3b-mediated extravascular hemolysis in certain complement-driven disorders such as paroxysmal nocturnal hemoglobinuria (PNH).;

UNII : 8E05T07Z6W;

InChIKey : RENRQMCACQEWFC-UGKGYDQZSA-N;

CAS number : 1644670-37-0;

Molecule name : LNP 023; LNP-023;

NCI Metathesaurus CUI : CL935722;

Codes from synonyms : 61269;

Details

Origin ID

C156691;

UMLS CUI

C5418258;

Currated CISMeF NLP mapping
- Iptacopan [SMS substance]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- iptacopan [MeSH Supplementary Concept]
- iptacopan [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Iptacopan Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Iptacopan Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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