Semaglutide - CISMeF

Preferred Label : Semaglutide;

NCIt definition : A glucagon-like peptide-1 (GLP-1) receptor agonist that is 94% homologous to human GLP-1 (7-37), with antihyperglycemic and appetite regulating activities. Upon administration, semaglutide binds to and activates GLP-1 receptor. In pancreatic beta cells, this increases glucose-dependent insulin release. Semaglutide also reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas and slows gastric emptying. Altogether this lowers the postprandial glucose level. In the brain, the binding to and activation of GLP-1 receptor suppresses appetite, which decreases caloric intake and lowers body weight. GLP-1 is normally secreted by L cells of the gastrointestinal (GI) mucosa in response to a meal to normalize blood glucose levels. It also plays an important role in the regulation of appetite and caloric intake.;

UNII : 53AXN4NNHX;

InChIKey : DLSWIYLPEUIQAV-CCUURXOWSA-N;

CAS number : 910463-68-2;

Drug name : Ozempic; Wegovy; Rybelsus;

NCI Metathesaurus CUI : CL553532;

Details

Origin ID

C152328;

UMLS CUI

C3885068;

Automatic exact mappings (from CISMeF team)
- semaglutide [ATC Code]
Currated CISMeF NLP mapping
- Semaglutide [ICD-11 Extension code]
- Semaglutide [SMS substance]
- Semaglutide (substance) [SNOMED CT concept]
- semaglutide [MeSH concept]
- semaglutide [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing semaglutide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing semaglutide (medicinal product) [SNOMED CT concept]
- Semaglutide (substance) [SNOMED CT concept]
- semaglutide [ATC Code]
- semaglutide [MeSH concept]
- semaglutide [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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