Adhesion G Protein-Coupled Receptor L3

Preferred Label : Adhesion G Protein-Coupled Receptor L3;

NCIt synonyms : Latrophilin 3; Lectomedin-3; Calcium-Independent Alpha-Latrotoxin Receptor 3; ADGRL3; Lectomedin 3; Latrophilin-3; CIRL-3;

NCIt definition : Adhesion G protein-coupled receptor L3 (1447 aa, 162 kDa) is encoded by the human ADGRL3 gene. This protein plays a role in G protein-coupled receptor signaling, neuronal migration and cell-cell adhesion.;

NCIt note : Adhesion G protein-coupled receptor L3 contains an extracellular S-lectin-like domain, followed by an olfactomedin domain, a mucin-like stretch, a cysteine box near the plasma membrane, 7 transmembrane domains, and a short intracellular tail. The cysteine box includes a potential proteolytic cleavage site that would yield 2 subunits, an extracellular subunit and a seven-transmembrane subunit. (OMIM and UniProt);

NCI Metathesaurus CUI : CL552025;

Details

Origin ID

C150275;

UMLS CUI

C4723807;

Automatic exact mappings (from CISMeF team)
- Adhesion g protein-coupled receptor l3 [OMIM gene]
- adhesion G protein-coupled receptor L3 [HGNC gene]
OMIM relation
- Adhesion g protein-coupled receptor l3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- ADGRL3 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Migration Induction [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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