Aldesleukin - CISMeF

Preferred Label : Aldesleukin;

NCIt synonyms : Recombinant Human IL-2; 125-L-Serine-2-133-interleukin 2; r-serHuIL-2;

NCIt related terms : recombinant human interleukin-2; Proleukin;

NCIt definition : A recombinant analog of the endogenous cytokine interleukin-2 (IL-2) with immunoregulatory and antineoplastic activities. Aldesleukin binds to and activates the IL-2 receptor, followed by heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains; activation of the tyrosine kinase Jak3; and phosphorylation of tyrosine residues on the IL-2R beta chain, resulting in an activated receptor complex. Various cytoplasmic signaling molecules are recruited to the activated receptor complex and become substrates for regulatory enzymes that are associated with the receptor complex. This agent enhances lymphocyte mitogenesis; stimulates long-term growth of human IL-2 dependent cell lines; enhances lymphocyte cytotoxicity; induces lymphokine-activated killer (LAK) cell and natural killer (NK) cell activities; and induces expression of interferon-gamma. Aldesleukin may induce T cell-mediated tumor regression in some tumor types.;

Alternative definition : NCI-GLOSS: A drug used to treat some types of cancer. It is a form of interleukin-2, a cytokine made by leukocytes (white blood cells), that is made in the laboratory. Aldesleukin increases the activity and growth of white blood cells called T lymphocytes and B lymphocytes. It is a type of biological response modifier.;

UNII : M89N0Q7EQR;

CAS number : 110942-02-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 110942-02-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Proleukin;

Codes from synonyms : CDR0000579605; CDR0000579601; CDR0000046679; 15;

Details

Origin ID

C1498;

UMLS CUI

C0218986;

Automatic exact mappings (from CISMeF team)
- Aldesleukin [ICD-11 Extension code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Aldesleukin (substance) [SNOMED CT concept]
- Product containing aldesleukin (medicinal product) [SNOMED CT concept]
- aldesleukin [ATC Code]
- aldesleukin [International Nonproprietary Name]
- aldesleukin [MeSH concept]
- aldesleukin [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- aldesleukin [ATC Code]
chemical_or_drug_affects_gene_product
- Interferon Gamma [NCIt concept]
- Interleukin-2 Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
- Receptor Activation Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Interleukin-2 Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Aldesleukin Intralesional Regimen [NCIt concept]
- Aldesleukin Regimen [NCIt concept]
- CVD-Aldesleukin-Interferon Alfa-2b Regimen [NCIt concept]
- High-dose Aldesleukin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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