EZB Diffuse Large B-Cell Lymphoma

Preferred Label : EZB Diffuse Large B-Cell Lymphoma;

NCIt synonyms : EZB DLBCL;

NCIt definition : A diffuse large B-cell lymphoma molecular subtype characterized by the presence of EZH2 gene mutations and BCL2 gene translocations. Patients who belong in this subtype have a favorable outcome. (NEJM 2018; 378: 1396-407);

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL551015;

Details

Origin ID

C148398;

UMLS CUI

C4725006;

Disease excludes abnormal cell
- Lymphocyte Predominant Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Plasmablastic Immunoblast [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
- Thymic B-Lymphocyte [NCIt concept]
Excludes anatomical site(s)
- Thymus Gland [NCIt concept]
- Vascular System [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Histiocytosis [NCIt concept]
disease_excludes_molecular_abnormality
- ALK Kinase Overexpression [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Large B-Lymphocyte [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Diffuse Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_has_molecular_abnormality
- BCL2 Gene Translocation [NCIt concept]
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- EZH2 Gene Mutation [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- BCL2 Gene [NCIt concept]
- EZH2 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
pathogenesis_of_disease_involves_gene
- BCL2 Gene [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- EZH2 Gene [NCIt concept]
- EZH2 wt Allele [NCIt concept]

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