NCIt synonyms : Enhancer of Zeste Homolog 2 (Drosophila) Gene; EZH2b; MGC9169; Enhancer of Zeste (Drosophila) Homolog 2 Gene; ENX-1; Enhancer of Zeste 2 Gene; WVS; KMT6; KMT6A; ENX1; WVS2; Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit wt Allele; Enhancer of Zeste, Drosophila, Homolog 2 Gene;
NCIt definition : Human EZH2 wild-type allele is located within 7q35-q36 and is approximately 77 kb
in length. This allele, which encodes enhancer of zeste homolog 2 protein, plays a
role in the repression of gene transcription and regulation of chromatin structure.
Overexpression of the EZH2 gene is associated with the progression of certain types
of cancer such as bladder carcinomas and prostate cancer.;
NCIt note : Expression levels of EZH2 mRNA are elevated in aggressive and invasive bladder carcinomas.
The EZH2 gene is also overexpressed in hormone-refractory, metastatic prostate cancer.
This gene produces three mRNA transcripts via alternative splicing which, in turn,
encode distinct protein isoforms.;