Preferred Label : PEG-conjugated TLR7/8 Agonist NKTR-262;
NCIt synonyms : TLR 7/8 Agonist NKTR-262; Toll-like Receptor 7/8 Agonist NKTR-262; TLR7/TLR8 Agonist NKTR-262;
NCIt definition : A formulation composed of an agonist of toll-like receptor (TLR) type 7 and 8 (TLR7/8)
that is attached to polyethylene glycol (PEG) via a hydrolyzable glycine linker, with
potential immunostimulating and antitumor activities. Upon intratumoral (IT) administration,
TLR7/8 agonist NKTR-262 binds to and activates TLR7 and 8, thereby activating TLR7/8-mediated
pathways. This stimulates the maturation and activation of antigen-presenting cells
(APCs), including dendritic cells (DCs). Activation of DCs results in the production
of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL)-
and B-lymphocyte-mediated immune responses against tumor-associated antigens (TAAs),
which lead to tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental
roles in the activation of the innate immune system, myeloid cell responses and tumor
antigen presentation. Pegylation of the TLR7/8 agonist enhances retention of this
agent in the tumor microenvironment (TME), provides local sustained release of the
TLR7/8 agonist, increases efficacy and reduces systemic exposure compared to the administration
of the naked TLR7/8 agonist alone.;
Molecule name : NKTR-262; NKTR 262;
NCI Metathesaurus CUI : CL550901;
Origin ID : C148289;
UMLS CUI : C4724962;
Semantic type(s)
- concept_is_in_subset
- has_target
