Insulin-Like Growth Factor 2 mRNA Binding Protein 2

Preferred Label : Insulin-Like Growth Factor 2 mRNA Binding Protein 2;

NCIt synonyms : Hepatocellular Carcinoma Autoantigen p62; IMP-2; IGF2BP2; IGF II mRNA Binding Protein 2; IGF2 mRNA-Binding Protein 2; IGF-II mRNA-Binding Protein 2; VICKZ Family Member 2;

NCIt definition : Insulin-like growth factor 2 mRNA-binding protein 2 (599 aa, 66 kDa) is encoded by the human IGF2BP2 gene. This protein plays a role in the translation, localization and stability of mRNA.;

NCIt note : Autoantibodies against insulin-like growth factor 2 mRNA-binding protein 2 are detected in sera from some patients with hepatocellular carcinoma. (UniProt); Insulin-like growth factor 2 mRNA-binding protein 2 binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs and to beta-actin/ACTB and MYC transcripts. (UniProt);

Details

Origin ID

C147851;

UMLS CUI

C1447796;

Automatic exact mappings (from CISMeF team)
- IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [ORDO Gene]
- Inner mitochondrial membrane peptidase, subunit 2 [OMIM gene]
- Insulin-like growth factor 2 mrna-binding protein 2 [OMIM gene]
- Signal peptide peptidase-like 3 [OMIM gene]
- insulin like growth factor 2 mRNA binding protein 2 [HGNC gene]
OMIM relation
- Insulin-like growth factor 2 mrna-binding protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IGF2BP2 protein, human [MeSH Supplementary Concept]
- IGF2BP2 protein, human [MeSH concept]
gene_encodes_gene_product
- IGF2BP2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Translation Process Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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